Azide-Propionyl-Val-Cit-PAB(m-PEG8)-MMAE Size:5mg Product Name 4-(methoxy-d3)benzonitrile Synonyms 4-(²H3)methoxybenzonitrile

Product Name 4-(methoxy-d3)benzonitrile Synonyms 4-(²H3)methoxybenzonitrile CAS Number  1404321-27-2 Related CAS Molecular Formula C8H7NO Molecular Weight 136

the reaction product is stable

Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500

Product Name 2-Chloro-6-methyl-N

852 Purity (HPLC) >= 95% Solubility DMSO

Azide-Propionyl-Val-Cit-PAB(m-PEG8)-MMAE Size:5mg Product Name 4-(methoxy-d3)benzonitrile Synonyms 4-(²H3)methoxybenzonitrileSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing